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LUX-Lung 5 is the first prospective trial to demonstrate the benefit of continued ErbB targeting post-progression, versus switching to single-agent chemotherapy.

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Forsythe B, Faulkner K: Safety and tolerability of gefitinib ('Iressa', ZD1839) in advanced NSCLC: overview of clinical experience.

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The drosophila Pi3k21b and Pi3k92e IPs using a tap-tagged system with a total of 202 () unique drosophila proteins and the human IPs generated 522 () total candidate proteins after common contaminants such as keratins, dermicidins, milk caseins, albumin, etc.

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Presentations of disease range from resectable tumors with microscopic metastases to lymph nodes to unresectable, bulky disease involving multiple nodal stations.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Adjuvant chemotherapy, with or without postoperative radiotherapy, in operablenonsmall-cell lung cancer: two meta-analyses of individual patient data.

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To determine whether STAT3 phosphorylation had a dose-response relationship with gefitinib resistance in CRC cells, the three CRC cell lines, including HT29, SW480 and C2BBel, were chosen for the experiments.

Proteins, drug targets and the mechanisms they control: the simple truth about complex networks.

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Observation of hepatotoxicity during long-term gefitinib administration in patients with non-small-cell lung cancer.

Similar results were obtained in H1299 and GLC82 (data not shown).

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Delayed-type diarrhea is defined as diarrhea occurring more than 24 hours after administration of irinotecan and is noncumulative and occurs at all dose levels.

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Of the 14 patients with lymphoid blast crisis who had a response to STI571, 12 relapsed a median of 58 days after the initiation of treatment (range, 42 to 123), 1 underwent hematopoietic stem-cell transplantation, and the data on 1 who was in remission at day 58 have been censored because of the short length of follow-up ( Figure 2 Time to Relapse in Patients with Myeloid or Lymphoid Blast Crisis Who Had a Response to STI571.

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Objective tumor response rates with gefitinib were higher among patients positive for EGFR mutation (37.

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Two smaller studies also reported OS results that favored concurrent over sequential chemotherapy and radiation, although the results did not reach statistical significance.

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However, smoking status did not significantly affect ORR and PFS in NSCLC patients with EGFR wild type gene.

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Nine (19 %) patients had received prior systemic therapy in a palliative context only, using the same agents, prior to commencing gefitinib.

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The choice of combination drugs, however, varies in different countries, but several studies have shown similar degrees of efficacy among different combinations in the treatment of advanced NSCLC ().

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First-line gefitinib therapy for elder advanced non-small cell lung cancer patients with epidermal growth factor receptor mutations: multicenter phase II trial (NEJ 003 study).

AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827.

En dos estudios más pequeños también se notificaron resultados de SG que favorecieron la quimioterapia y radiación simultáneas contra la quimioterapia y la radiación consecutivas, aunque los resultados no alcanzaron significación estadística.

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